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polk-1 DNA polymerase kappa [ Caenorhabditis elegans ]

Gene ID: 176209, updated on 4-Jan-2025

Summary

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Official Symbol
polk-1
Official Full Name
DNA polymerase kappa
Primary source
WormBase:WBGene00017696
Locus tag
CELE_F22B7.6
See related
AllianceGenome:WB:WBGene00017696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development and error-prone translesion synthesis. Predicted to be active in nucleus. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See polk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (8626258..8628590, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Homeobox protein engrailed-like ceh-16 Neighboring gene G-protein regulator 1 Neighboring gene DnaJ homolog dnj-10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. Koole W, et al. Nat Commun, 2014. PMID 24496117
  2. Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex. van Schendel R, et al. Sci Adv, 2021 May. PMID 34138739, Free PMC Article
  3. Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Youds JL, et al. Genetics, 2006 Jun. PMID 16547095, Free PMC Article
  4. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
  5. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. Holway AH, et al. J Cell Biol, 2006 Mar 27. PMID 16549501, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMO-mediated regulation of both POLH-1 and POLK-1, and point towards a previously unrecognized role of the nuclear pore in regulating Translesion synthesis .
    Title: A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in error-prone translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase kappa
NP_001122692.1
  • Confirmed by transcript evidence
NP_001379588.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8626258..8628590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129220.3 → NP_001122692.1  DNA polymerase kappa [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122692.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WFE8, A8WFE9, P34409
    Conserved Domains (2) summary
    cd03586
    Location:86 → 473
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:90 → 473
    PRK02406; DNA polymerase IV; Validated

  2. NM_001392159.1 → NP_001379588.1  DNA polymerase kappa [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd03586
    Location:1 → 340
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34409.3

Gene LinkOut

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