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dnj-10 DnaJ homolog dnj-10 [ Caenorhabditis elegans ]

Gene ID: 176211, updated on 9-Dec-2024

Summary

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Official Symbol
dnj-10
Official Full Name
DnaJ homolog dnj-10
Primary source
WormBase:WBGene00001028
Locus tag
CELE_F22B7.5
See related
AllianceGenome:WB:WBGene00001028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Involved in embryo development and nematode larval development. Predicted to be active in mitochondrion. Is expressed in head; intestine; pharynx; and tail. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dnj-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (8631165..8633565)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein engrailed-like ceh-16 Neighboring gene DNA polymerase kappa Neighboring gene G-protein regulator 1 Neighboring gene TWiK family of potassium channels protein 7 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Fungus-induced protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Dhananjay S, et al. MicroPubl Biol, 2022. PMID 36530473, Free PMC Article
  2. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Nargund AM, et al. Science, 2012 Aug 3. PMID 22700657, Free PMC Article
  3. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article
  4. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Poteryaev D, et al. Mol Biol Cell, 2005 May. PMID 15716356, Free PMC Article
  5. Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans. Kropp PA, et al. PLoS Genet, 2021 Aug. PMID 34449775, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
DnaJ homolog dnj-10
NP_498901.1
  • Confirmed by transcript evidence
NP_498902.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8631165..8633565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066501.4 → NP_498902.1  DnaJ homolog dnj-10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34408, Q8TA83, Q95QJ6
    Conserved Domains (4) summary
    cd10719
    Location:191 → 252
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:165 → 372
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:41 → 387
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:44 → 105
    DnaJ; DnaJ domain

  2. NM_066500.7 → NP_498901.1  DnaJ homolog dnj-10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8TA83
    Conserved Domains (4) summary
    cd10719
    Location:191 → 252
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:165 → 372
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:41 → 387
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:44 → 105
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TA83.1

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