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vps-33.1 Vacuolar protein sorting-associated protein 33A [ Caenorhabditis elegans ]

Gene ID: 176221, updated on 2-Nov-2024

Summary

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Official Symbol
vps-33.1
Official Full Name
Vacuolar protein sorting-associated protein 33A
Primary source
WormBase:WBGene00015130
Locus tag
CELE_B0303.9
See related
AllianceGenome:WB:WBGene00015130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in apical plasma membrane; early endosome; and late endosome. Predicted to be part of CORVET complex and HOPS complex. Predicted to be active in lysosome. Is expressed in several structures, including body wall musculature; coelomocyte; intestine; pharynx; and spermatheca. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-33.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (8700927..8703341)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene SH3 domain-containing protein Neighboring gene Skn-1 dependent zygotic transcript 1 protein Neighboring gene Solute carrier family 12 protein B0303.11 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans. Gengyo-Ando K, et al. Traffic, 2016 Nov. PMID 27558849
  2. Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans. Solinger JA, et al. Mol Biol Cell, 2014 Dec 1. PMID 25273556, Free PMC Article
  3. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Xiao H, et al. Mol Biol Cell, 2009 Jan. PMID 18923146, Free PMC Article
  4. Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Delahaye JL, et al. Mol Biol Cell, 2014 Apr. PMID 24501423, Free PMC Article
  5. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Samuelson AV, et al. Genes Dev, 2007 Nov 15. PMID 18006689, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that simultaneous loss of the Sec1/Munc18-family proteins (SM) proteins VPS-33.1 and VPS-33.2 bypasses the endocytosis block.
    Title: Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CORVET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HOPS complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vacuolar protein sorting-associated protein 33A
NP_498920.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8700927..8703341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066519.5 → NP_498920.2  Vacuolar protein sorting-associated protein 33A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498920.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34260
    Conserved Domains (1) summary
    pfam00995
    Location:44 → 435
    Sec1; Sec1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34260.4

Gene LinkOut

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