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aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [ Caenorhabditis elegans ]

Gene ID: 176230, updated on 9-Dec-2024

Summary

Official Symbol
aak-1
Official Full Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Primary source
WormBase:WBGene00019801
Locus tag
CELE_PAR2.3
See related
AllianceGenome:WB:WBGene00019801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of cell population proliferation and nematode pharyngeal pumping. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See aak-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (8756990..8761090, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dwarfin sma-2;MH2 domain-containing protein Neighboring gene Mitochondrial import receptor subunit tomm-70 Neighboring gene ncRNA Neighboring gene Chondroitin sulfate synthase mig-22 Neighboring gene Single-stranded DNA-binding protein, mitochondrial

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-1
NP_001380007.1
  • Confirmed by transcript evidence
NP_741254.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8756990..8761090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392162.1NP_001380007.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd14336
    Location:121185
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cl17070
    Location:219308
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  2. NM_171216.6NP_741254.3  5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741254.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45894, Q3HKC8, Q3HKC9, Q5VKL2
    Conserved Domains (4) summary
    cd12122
    Location:390479
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:24276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:292356
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cl21453
    Location:21276
    PKc_like; Protein Kinases, catalytic domain