gst-1 Glutathione S-transferase P [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gst-1
Official Full Name: Glutathione S-transferase P
Primary source: WormBase:WBGene00001749
Locus tag: CELE_R107.7
See related: AllianceGenome:WB:WBGene00001749
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables glutathione transferase activity. Involved in several processes, including defense response to other organism; negative regulation of cellular response to manganese ion; and positive regulation of cellular response to manganese ion. Predicted to be active in cytosol. Is expressed in DA neuron. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); eye disease (multiple); hematopoietic system disease (multiple); and respiratory system disease (multiple). Orthologous to several human genes including GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gst-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (9059331..9060181)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans Nrf2/SKN-1-dependent GSTpi homologue, cell death effectors of GSTpi-associated xenobiotic-induced pathology, and provides the first in vivo evidence that a phase II detoxification enzyme may modulate DA neuron vulnerability in manganism
Title: The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R107.7 (e-PCR)
- UniSTS:316974

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in cellular detoxification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular response to manganese ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular response to manganese ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glutathione S-transferase P

NP_499006.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9059331..9060181

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066605.9 → NP_499006.1 Glutathione S-transferase P [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499006.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P10299

Conserved Domains (3) summary

PTZ00057
Location:5 → 195

PTZ00057; glutathione s-transferase; Provisional

cd03210
Location:81 → 208

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:2 → 72

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...