ufc-1 Ubiquitin-fold modifier-conjugating enzyme 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ufc-1
Official Full Name: Ubiquitin-fold modifier-conjugating enzyme 1
Primary source: WormBase:WBGene00008041
Locus tag: CELE_C40H1.6
See related: AllianceGenome:WB:WBGene00008041
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin conjugating enzyme binding activity. Predicted to be involved in response to endoplasmic reticulum stress and reticulophagy. Located in striated muscle dense body. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ufc-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (9331514..9332284)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C40H1.5 (e-PCR)
- UniSTS:320883

C40H1.6 (e-PCR)
- UniSTS:320884

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UFM1 conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables UFM1 transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein ufmylation	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: Ubiquitin-fold modifier-conjugating enzyme 1

NP_499055.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9331514..9332284

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066654.7 → NP_499055.1 Ubiquitin-fold modifier-conjugating enzyme 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499055.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03598

Conserved Domains (1) summary

pfam08694
Location:5 → 159

UFC1; Ubiquitin-fold modifier-conjugating enzyme 1