crn-6 Cell death-related nuclease 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crn-6
Official Full Name: Cell death-related nuclease 6
Primary source: WormBase:WBGene00000799
Locus tag: CELE_K04H4.6
See related: AllianceGenome:WB:WBGene00000799
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Is expressed in intestinal cell and seam cell. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See crn-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (9367271..9370381)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04H4.6 (e-PCR)
- UniSTS:311415

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables deoxyribonuclease II activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonuclease II activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease II activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic DNA fragmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic DNA fragmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cell death-related nuclease 6

NP_001370104.1

Confirmed by transcript evidence

NP_499061.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9367271..9370381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066660.6 → NP_499061.2 Cell death-related nuclease 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499061.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34508, Q9NAQ0, Q9NCF8

Conserved Domains (3) summary

cd09120
Location:17 → 161

PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins

cd09121
Location:208 → 356

PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins

pfam03265
Location:20 → 352

DNase_II; Deoxyribonuclease II
NM_001382961.2 → NP_001370104.1 Cell death-related nuclease 6 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam03265
Location:22 → 343

DNase_II; Deoxyribonuclease II