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rgr-1 Mediator of RNA polymerase II transcription subunit 14 [ Caenorhabditis elegans ]

Gene ID: 176320, updated on 4-Jan-2025

Summary

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Official Symbol
rgr-1
Official Full Name
Mediator of RNA polymerase II transcription subunit 14
Primary source
WormBase:WBGene00004343
Locus tag
CELE_C38C10.5
See related
AllianceGenome:WB:WBGene00004343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in germ line; hypodermis; intestine; and pharynx. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rgr-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (9393730..9404541)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative G-protein coupled receptor tkr-1 Neighboring gene putative transporter slc-17.2 Neighboring gene G-protein regulator 2 Neighboring gene Neuropeptide-Like Protein Neighboring gene Putative ATP-dependent RNA helicase T26G10.1 Neighboring gene pseudo Neighboring gene Small ribosomal subunit protein eS24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo. Shim EY, et al. J Biol Chem, 2002 Aug 23. PMID 12089139
  2. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Kwon JY, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611325, Free PMC Article
  3. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. Walker AK, et al. J Biol Chem, 2003 Feb 21. PMID 12458202
  4. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. Walker AK, et al. J Biol Chem, 2004 Apr 9. PMID 14726532
  5. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 14
NP_001359524.1
  • Confirmed by transcript evidence
NP_499067.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9393730..9404541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372642.1 → NP_001359524.1  Mediator of RNA polymerase II transcription subunit 14 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D2Y8V9, P34581, P39218, Q03570
    Conserved Domains (1) summary
    pfam08638
    Location:6 → 170
    Med14; Mediator complex subunit MED14

  2. NM_066666.5 → NP_499067.3  Mediator of RNA polymerase II transcription subunit 14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499067.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D2Y8V9, P34581, P39218, Q03570
    Conserved Domains (1) summary
    pfam08638
    Location:6 → 172
    Med14; Mediator complex subunit MED14
Nucleotide Protein
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