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cbp-1 Protein cbp-1 [ Caenorhabditis elegans ]

Gene ID: 176380, updated on 9-Dec-2024

Summary

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Official Symbol
cbp-1
Official Full Name
Protein cbp-1
Primary source
WormBase:WBGene00000366
Locus tag
CELE_R10E11.1
See related
AllianceGenome:WB:WBGene00000366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; histone acetyltransferase activity; and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of distal tip cell migration; and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; body wall musculature; distal tip cell; nervous system; and tail. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; and congestive heart failure. Orthologous to several human genes including CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cbp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (9766510..9774825)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GRIP and coiled-coil domain-containing protein 2 Neighboring gene Regulator of microtubule dynamics protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase 46 Neighboring gene Xylosylprotein 4-beta-galactosyltransferase Neighboring gene V-type proton ATPase 16 kDa proteolipid subunit c 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress. Zhou L, et al. PLoS Genet, 2019 Apr. PMID 31034475, Free PMC Article
  2. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. Lublin A, et al. PLoS One, 2011. PMID 22114686, Free PMC Article
  3. Cannabidiol regulates CB1-pSTAT3 signaling for neurite outgrowth, prolongs lifespan, and improves health span in Caenorhabditis elegans of Aβ pathology models. Wang Z, et al. FASEB J, 2021 May. PMID 33817834
  4. Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR. Snow S, et al. Front Biosci (Landmark Ed), 2024 Jul 23. PMID 39082355, Free PMC Article
  5. CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans. Cai H, et al. J Gerontol A Biol Sci Med Sci, 2019 Jul 12. PMID 29099917, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.
    Title: Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.
  2. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
    Title: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
  3. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
    Title: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
  4. cbp-1 is induced by bacterial dilution dietary restriction (bDR)
    Title: Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
  5. CRE-mediated transcription in a subset of head neurons in living nematodes is regulated by the CaMK cascade
    Title: A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-lysine-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of distal tip cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein cbp-1
NP_001122711.2
  • Confirmed by transcript evidence
NP_499160.2
  • Confirmed by transcript evidence
NP_499161.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9766510..9774825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066759.5 → NP_499160.2  Protein cbp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499160.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B0M0M3, P34545
    Conserved Domains (8) summary
    cd05495
    Location:866 → 972
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1551 → 1629
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1497 → 1535
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:984 → 1067
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1069 → 1100
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02172
    Location:593 → 673
    KIX; KIX domain
    pfam06001
    Location:970 → 1009
    DUF902; Domain of Unknown Function (DUF902)
    cl02120
    Location:1131 → 1427
    HAT_KAT11; Histone acetylation protein

  2. NM_001129239.3 → NP_001122711.2  Protein cbp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122711.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34545
    Conserved Domains (9) summary
    cd05495
    Location:855 → 961
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1540 → 1618
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1486 → 1524
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:973 → 1056
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1058 → 1089
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02135
    Location:415 → 491
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:582 → 662
    KIX; KIX domain
    pfam06001
    Location:959 → 998
    DUF902; Domain of Unknown Function (DUF902)
    cl02120
    Location:1120 → 1416
    HAT_KAT11; Histone acetylation protein

  3. NM_066760.8 → NP_499161.2  Protein cbp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499161.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34545
    Conserved Domains (9) summary
    cd05495
    Location:855 → 961
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1540 → 1618
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1486 → 1524
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:973 → 1056
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1058 → 1089
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02135
    Location:415 → 491
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:582 → 662
    KIX; KIX domain
    pfam06001
    Location:959 → 998
    DUF902; Domain of Unknown Function (DUF902)
    cl02120
    Location:1120 → 1416
    HAT_KAT11; Histone acetylation protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34545.6

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