mua-3 Transmembrane cell adhesion receptor mua-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mua-3
Official Full Name: Transmembrane cell adhesion receptor mua-3
Primary source: WormBase:WBGene00003482
Locus tag: CELE_K08E5.3
See related: AllianceGenome:WB:WBGene00003482
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable collagen binding activity and intermediate filament binding activity. Involved in cell-matrix adhesion. Located in hemidesmosome and intermediate filament. Is expressed in several structures, including amphid neurons; enteric muscle; excretory system; phasmid sensillum; and rectum. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5; osteoarthritis; and osteochondrodysplasia. Orthologous to human MATN3 (matrilin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mua-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 36

Sequence:: Chromosome: III; NC_003281.10 (10160697..10183529)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MUA-3 acts at the apical hypodermal surface to maintain the attachment of the hypodermis to the basal cuticle and that the primary defect in mua-3 mutants is the failure of these attachments.
Title: DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08E5.3 (e-PCR)
- UniSTS:314640

T20G5.3 (e-PCR)
- UniSTS:310916

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables intermediate filament binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transmembrane cell adhesion receptor mua-3

NP_001022674.1

Confirmed by transcript evidence

NP_001022675.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10160697..10183529

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027503.4 → NP_001022674.1 Transmembrane cell adhesion receptor mua-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022674.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34576, Q21340, Q65ZC2, Q9UA13

Conserved Domains (5) summary

smart00179
Location:3328 → 3364

EGF_CA; Calcium-binding EGF-like domain

smart00200
Location:3049 → 3173

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00112
Location:131 → 164

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd01482
Location:1229 → 1398

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam12947
Location:766 → 795

EGF_3; EGF domain
NM_001027504.3 → NP_001022675.1 Transmembrane cell adhesion receptor mua-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022675.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34576

Conserved Domains (4) summary

smart00179
Location:2744 → 2780

EGF_CA; Calcium-binding EGF-like domain

smart00200
Location:2465 → 2589

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd01482
Location:645 → 814

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam12947
Location:182 → 211

EGF_3; EGF domain