chl-1 ATP-dependent DNA helicase chl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: chl-1
Official Full Name: ATP-dependent DNA helicase chl-1
Primary source: WormBase:WBGene00010839
Locus tag: CELE_M03C11.2
See related: AllianceGenome:WB:WBGene00010839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA helicase activity. Involved in positive regulation of cell population proliferation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See chl-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (10399174..10405240, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results demonstrate a role for CHL-1 (M03C11.2) in cell proliferation and maintaining normal chromosome numbers.
Title: CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M03C11.2 (e-PCR)
- UniSTS:314692

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in establishment of sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent DNA helicase chl-1

NP_499295.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10399174..10405240 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066894.8 → NP_499295.2 ATP-dependent DNA helicase chl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499295.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21489

Conserved Domains (3) summary

TIGR00604
Location:121 → 820

rad3; DNA repair helicase (rad3)

pfam13307
Location:632 → 803

Helicase_C_2; Helicase C-terminal domain

cl21455
Location:2 → 387

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases