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unc-49 Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 176472, updated on 14-Nov-2024

Summary

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Official Symbol
unc-49
Official Full Name
Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein
Primary source
WormBase:WBGene00006784
Locus tag
CELE_T21C12.1
See related
AllianceGenome:WB:WBGene00006784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Is expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-49 in Genome Data Viewer
Location:
chromosome: III
Exon count:
26
Sequence:
Chromosome: III; NC_003281.10 (10520762..10532705)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Sec1 family domain-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 4-hydroxyphenylpyruvate dioxygenase Neighboring gene ncRNA Neighboring gene Neuropeptide-like protein 68

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of epilepsy-associated GABA(A) receptor mutations using Caenorhabditis elegans. Gadhia A, et al. Epilepsia Open, 2024 Aug. PMID 38813985, Free PMC Article
  2. The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction. Bamber BA, et al. Br J Pharmacol, 2005 Feb. PMID 15655525, Free PMC Article
  3. Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. Wardell B, et al. Br J Pharmacol, 2006 May. PMID 16547524, Free PMC Article
  4. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Twede V, et al. Mol Pharmacol, 2007 Nov. PMID 17715402
  5. Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Bamber BA, et al. Br J Pharmacol, 2003 Mar. PMID 12642390, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
    Title: UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
  2. GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
    Title: GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of backward locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein
NP_001022783.1
  • Partially confirmed by transcript evidence
NP_001022784.1
  • Partially confirmed by transcript evidence
NP_001022785.1
  • Partially confirmed by transcript evidence
NP_001022786.1
  • Confirmed by transcript evidence
NP_001076648.1
  • Confirmed by transcript evidence
NP_001293662.1
  • Partially confirmed by transcript evidence
NP_001293663.1
  • Confirmed by transcript evidence
NP_001368253.1
  • Confirmed by transcript evidence
NP_001368254.1
  • Partially confirmed by transcript evidence
NP_001370908.1
  • Confirmed by transcript evidence
NP_001379283.1
  • Confirmed by transcript evidence
NP_001379457.1
  • Confirmed by transcript evidence
NP_001380139.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10520762..10532705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027612.4 → NP_001022783.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEY3
    Conserved Domains (3) summary
    TIGR00860
    Location:37 → 465
    LIC; Cation transporter family protein
    pfam02931
    Location:37 → 248
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:260 → 463
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001027613.3 → NP_001022784.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFN4
    Conserved Domains (3) summary
    TIGR00860
    Location:37 → 453
    LIC; Cation transporter family protein
    pfam02931
    Location:37 → 248
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:260 → 451
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001027615.4 → NP_001022786.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE10
    Conserved Domains (3) summary
    TIGR00860
    Location:37 → 423
    LIC; Cation transporter family protein
    pfam02931
    Location:37 → 222
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261 → 421
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. NM_001027614.4 → NP_001022785.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECD3
    Conserved Domains (3) summary
    TIGR00860
    Location:37 → 484
    LIC; Cation transporter family protein
    pfam02931
    Location:37 → 248
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:260 → 482
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  5. NM_001392191.1 → NP_001379283.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBQ0
    Conserved Domains (1) summary
    TIGR00860
    Location:37 → 471
    LIC; Cation transporter family protein

  6. NM_001392190.1 → NP_001380139.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBP4
    Conserved Domains (1) summary
    TIGR00860
    Location:37 → 465
    LIC; Cation transporter family protein

  7. NM_001382981.2 → NP_001370908.1  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBB4
    Conserved Domains (2) summary
    cd03558
    Location:167 → 181
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:60 → 187
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  8. NM_001306734.3 → NP_001293663.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBC0
    Conserved Domains (2) summary
    pfam02931
    Location:1 → 54
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:93 → 253
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  9. NM_001379902.1 → NP_001368254.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRE0
    Conserved Domains (1) summary
    TIGR00860
    Location:1 → 297
    LIC; Cation transporter family protein

  10. NM_001379903.1 → NP_001368253.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PM48
    Conserved Domains (1) summary
    TIGR00860
    Location:1 → 303
    LIC; Cation transporter family protein

  11. NM_001306733.3 → NP_001293662.1  Uncharacterized protein CELE_T21C12.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEJ2
    Conserved Domains (1) summary
    pfam02932
    Location:36 → 56
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  12. NM_001392193.1 → NP_001379457.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDM9
    Conserved Domains (2) summary
    TIGR00860
    Location:3 → 239
    LIC; Cation transporter family protein
    cd19049
    Location:72 → 237
    LGIC_TM_anion; transmembrane domain of anionic Cys-loop neurotransmitter-gated ion channels, includes GABAAR, GlyR and GluCl

  13. NM_001083179.4 → NP_001076648.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0PDK2
    Conserved Domains (2) summary
    cd03559
    Location:24 → 105
    LGIC_TM; TM3 helix [structural motif]
    cl38911
    Location:1 → 130
    LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
Nucleotide Protein
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