acdh-11 Acyl-CoA dehydrogenase family member 11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acdh-11
Official Full Name: Acyl-CoA dehydrogenase family member 11
Primary source: WormBase:WBGene00012860
Locus tag: CELE_Y45F3A.3
See related: AllianceGenome:WB:WBGene00012860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables fatty acid binding activity. Involved in adaptive thermogenesis. Is expressed in head; hypodermis; intestine; nervous system; and rectal gland cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See acdh-11 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (10566258..10571603)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study solved the high-resolution crystal structure of ACDH-11 and established the molecular basis of its selective and high-affinity binding to C11/C12-chain fatty acids. ACDH-11 sequesters C11/C12-chain fatty acids and prevents these fatty acids from activating nuclear hormone receptors and driving fat-7 expression.
Title: Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y45F3A.3 (e-PCR)
- UniSTS:305995

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acyl-CoA dehydrogenase family member 11

NP_001033378.1

Partially confirmed by transcript evidence

NP_001379451.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10566258..10571603

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038289.7 → NP_001033378.1 Acyl-CoA dehydrogenase family member 11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033378.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3T978, Q9XWZ2

Conserved Domains (2) summary

cd01154
Location:46 → 480

AidB; Proteins involved in DNA damage response, similar to the AidB gene product

cl09933
Location:420 → 569

ACAD; Acyl-CoA dehydrogenase
NM_001392194.1 → NP_001379451.1 Acyl-CoA dehydrogenase family member 11 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd01154
Location:37 → 471

AidB; Proteins involved in DNA damage response, similar to the AidB gene product

cl09933
Location:411 → 560

ACAD; Acyl-CoA dehydrogenase