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tat-3 Phospholipid-transporting ATPase [ Caenorhabditis elegans ]

Gene ID: 176498, updated on 2-Nov-2024

Summary

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Official Symbol
tat-3
Official Full Name
Phospholipid-transporting ATPase
Primary source
WormBase:WBGene00012360
Locus tag
CELE_W09D10.2
See related
AllianceGenome:WB:WBGene00012360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anchor cell; distal tip cell; epithelial cell; pharyngeal-intestinal valve; and pharynx. Orthologous to several human genes including ATP10A (ATPase phospholipid transporting 10A (putative)) and ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tat-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (10722148..10730705, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene N-acetylgalactosaminide beta-1,3-galactosyltransferase Neighboring gene Protein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Arf-GAP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans. Lyssenko NN, et al. Biotechniques, 2007 Nov. PMID 18072588
  2. An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. Lyssenko NN, et al. BMC Dev Biol, 2008 Oct 2. PMID 18831765, Free PMC Article
  3. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785
  4. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phospholipid-transporting ATPase
NP_499363.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10722148..10730705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066962.5 → NP_499363.3  Phospholipid-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499363.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18182
    Conserved Domains (5) summary
    TIGR01652
    Location:103 → 1357
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:770 → 848
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:94 → 152
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1107 → 1356
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1075 → 1107
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
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