dpy-28 Condensin complex subunit 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-28
Official Full Name: Condensin complex subunit 1
Primary source: WormBase:WBGene00001087
Locus tag: CELE_Y39A1B.3
See related: AllianceGenome:WB:WBGene00001087
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone binding activity. Involved in meiotic sister chromatid segregation; mitotic sister chromatid segregation; and negative regulation of reciprocal meiotic recombination. Located in X chromosome and nucleus. Part of dosage compensation complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dpy-28 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (10763131..10777076)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings identify a Structural Maintenance of Chromosomes (SMC)-like protein, SMCL-1 (C44C10.4), that binds to condensin subunits dpy-26, dpy-27 and dpy-28 and modulates condensin functions.
Title: An SMC-like protein binds and regulates Caenorhabditis elegans condensins.
Our work further links dosage compensation to condensin and establishes a new role for condensin components in regulating crossover number and distribution
Title: Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39A1B.3 (e-PCR)
- UniSTS:312852

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in condensed chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dosage compensation complex	IPI Inferred from Physical Interaction more info	PubMed
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Condensin complex subunit 1

NP_499379.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10763131..10777076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066978.6 → NP_499379.2 Condensin complex subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499379.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M1

UniProtKB/TrEMBL

Q965E3

Conserved Domains (3) summary

sd00044
Location:380 → 418

HEAT; HEAT repeat [structural motif]

pfam12717
Location:1178 → 1327

Cnd1; non-SMC mitotic condensation complex subunit 1

cl26274
Location:358 → 1308

Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term