rle-1 Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rle-1
Official Full Name: Regulation of longevity by E3 ubiquitin-protein ligase
Primary source: WormBase:WBGene00010923
Locus tag: CELE_M142.6
See related: AllianceGenome:WB:WBGene00010923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin-protein transferase activity. Involved in determination of adult lifespan; response to heat; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasmic stress granule. Is expressed in several structures, including hypodermis; intestine; and reproductive system. Orthologous to several human genes including RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rle-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (10936244..10947330)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RLE-1 is an E3 ubiquitin ligase of DAF-16 that regulates C. elegans aging.
Title: RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M142.6 (e-PCR)
- UniSTS:311994

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Regulation of longevity by E3 ubiquitin-protein ligase

NP_001366782.1

Confirmed by transcript evidence

NP_001367283.1

Confirmed by transcript evidence

NP_001367296.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10936244..10947330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379917.1 → NP_001367296.1 Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

pfam18386
Location:266 → 321

ROQ_II; Roquin II domain

cl17238
Location:13 → 56

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001379916.1 → NP_001366782.1 Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

F5GUI8, G5EDG1, O45962, Q93898

Conserved Domains (2) summary

pfam18386
Location:266 → 321

ROQ_II; Roquin II domain

cl17238
Location:13 → 56

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001379918.1 → NP_001367283.1 Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED