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Y48A6B.9 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176534, updated on 4-Jan-2025

Summary

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Official Symbol
Y48A6B.9
Official Full Name
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Primary source
WormBase:WBGene00012970
Locus tag
CELE_Y48A6B.9
See related
AllianceGenome:WB:WBGene00012970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Y48A6B.9 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (11033172..11036088)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Wsv161 Neighboring gene NR LBD domain-containing protein Neighboring gene Protein lilliputian;Suppressor of PAr-Two defect Neighboring gene Regulator of spindle assembly protein 2 Neighboring gene ncRNA Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
NP_001255097.1
  • Confirmed by transcript evidence
NP_001255098.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11033172..11036088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268168.3 → NP_001255097.1  Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XXC8
    Conserved Domains (2) summary
    cd08290
    Location:7 → 337
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:8 → 337
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

  2. NM_001268169.4 → NP_001255098.1  Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3Y5Q6
    Conserved Domains (1) summary
    cl16912
    Location:1 → 86
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XXC8.1

Gene LinkOut

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