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obr-1 Oxysterol-binding protein [ Caenorhabditis elegans ]

Gene ID: 176555, updated on 2-Nov-2024

Summary

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Official Symbol
obr-1
Official Full Name
Oxysterol-binding protein
Primary source
WormBase:WBGene00012930
Locus tag
CELE_Y47D3A.17
See related
AllianceGenome:WB:WBGene00012930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sterol binding activity. Predicted to be involved in lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See obr-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
17
Sequence:
Chromosome: III; NC_003281.10 (11257300..11270895, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S6 kinase beta Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multivesicular body formation requires OSBP-related proteins and cholesterol. Kobuna H, et al. PLoS Genet, 2010 Aug 5. PMID 20700434, Free PMC Article
  2. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Park WS, et al. Mol Cell, 2008 May 9. PMID 18471983, Free PMC Article
  3. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Oxysterol-binding protein
NP_001122730.1
  • Confirmed by transcript evidence
NP_001367172.1
  • Confirmed by transcript evidence
NP_001367300.1
  • Confirmed by transcript evidence
NP_001379284.1
  • Confirmed by transcript evidence
NP_499448.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11257300..11270895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067047.6 → NP_499448.1  Oxysterol-binding protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2C7
    Conserved Domains (3) summary
    pfam00169
    Location:61 → 150
    PH; PH domain
    pfam01237
    Location:382 → 746
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:63 → 162
    PH-like; Pleckstrin homology-like domain

  2. NM_001129258.5 → NP_001122730.1  Oxysterol-binding protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7DTF3
    Conserved Domains (1) summary
    pfam01237
    Location:65 → 429
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001392212.1 → NP_001379284.1  Oxysterol-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q23
    Conserved Domains (2) summary
    COG4372
    Location:4 → 178
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam01237
    Location:243 → 613
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_001379928.1 → NP_001367300.1  Oxysterol-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2HK04
    Conserved Domains (3) summary
    COG4372
    Location:92 → 283
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam01237
    Location:348 → 718
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:29 → 128
    PH-like; Pleckstrin homology-like domain

  5. NM_001379929.1 → NP_001367172.1  Oxysterol-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7DTF2
    Conserved Domains (3) summary
    COG4372
    Location:202 → 393
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam01237
    Location:458 → 828
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:170 → 238
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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