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mib-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176558, updated on 2-Nov-2024

Summary

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Official Symbol
mib-1
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00012933
Locus tag
CELE_Y47D3A.22
See related
AllianceGenome:WB:WBGene00012933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in vulva. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1) and MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mib-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (11286335..11290676, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Density-regulated protein homolog Neighboring gene putative N-acetylgalactosaminyltransferase 9 Neighboring gene Structural maintenance of chromosomes protein 3 Neighboring gene Ras-related protein Rab-35

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity in Caenorhabditis elegans. Ratliff M, et al. Genetics, 2018 May. PMID 29531012, Free PMC Article
  2. The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm. Herrera LA, et al. G3 (Bethesda), 2018 Jul 2. PMID 29776970, Free PMC Article
  3. The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Kwon DY, et al. Mol Biol Cell, 2013 Jun. PMID 23615451, Free PMC Article
  4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt JD, et al. J Cell Biol, 2011 Sep 5. PMID 21875946, Free PMC Article
  5. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that knocking down Y47D3A.22/mib-1 improves neuromuscular function in Caenorhabditis elegans deficient in SMN-1.
    Title: The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.
  2. ceMIB (Caenorhabditis elegans Mindbomb/Y47D3A.22) plays a role in the regulation of C. elegans Wnt/RYK (lin-18) /TCF signaling.
    Title: Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_499452.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11286335..11290676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067051.7 → NP_499452.2  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499452.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2C5
    Conserved Domains (5) summary
    cd00204
    Location:341 → 459
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:420 → 494
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:382 → 436
    Ank_4; Ankyrin repeats (many copies)
    pfam13920
    Location:717 → 760
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:384 → 413
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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