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pen-2 Gamma-secretase subunit pen-2 [ Caenorhabditis elegans ]

Gene ID: 176565, updated on 9-Dec-2024

Summary

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Official Symbol
pen-2
Official Full Name
Gamma-secretase subunit pen-2
Primary source
WormBase:WBGene00003975
Locus tag
CELE_T28D6.9
See related
AllianceGenome:WB:WBGene00003975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including Notch signaling pathway; germ cell development; and pharynx development. Located in membrane. Is expressed in intestine; muscle cell; neurons; and vulva. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pen-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (11343322..11344147)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein MCM10 homolog Neighboring gene GTP-binding protein 128up;OBG-type G domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene START domain-containing protein Neighboring gene tRNA-Val Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. Brinkley DM, et al. Genetics, 2024 Jul 8. PMID 38717968
  2. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. Edbauer D, et al. J Biol Chem, 2004 Sep 3. PMID 15210705
  3. Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. Alexander AG, et al. Front Genet, 2014. PMID 25250042, Free PMC Article
  4. Genetics leads the way to the accomplices of presenilins. Goutte C. Dev Cell, 2002 Jul. PMID 12110162
  5. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Ma T, et al. Nature, 2022 Mar. PMID 35197629, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Notch receptor processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-secretase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-secretase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gamma-secretase subunit pen-2
NP_499459.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11343322..11344147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067058.6 → NP_499459.1  Gamma-secretase subunit pen-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U357
    Conserved Domains (1) summary
    pfam10251
    Location:7 → 99
    PEN-2; Presenilin enhancer-2 subunit of gamma secretase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U357.1

Gene LinkOut

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