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sbp-1 Processed sterol regulatory element binding protein sbp-1 [ Caenorhabditis elegans ]

Gene ID: 176574, updated on 2-Nov-2024

Summary

Official Symbol
sbp-1
Official Full Name
Processed sterol regulatory element binding protein sbp-1
Primary source
WormBase:WBGene00004735
Locus tag
CELE_Y47D3B.7
See related
AllianceGenome:WB:WBGene00004735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to zinc ion; fatty acid metabolic process; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Is expressed in several structures, including head; intestine; and terminal bulb. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to several human genes including SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See sbp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (11428367..11442566, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative E3 ubiquitin-protein ligase plr-1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Processed sterol regulatory element binding protein sbp-1
NP_499472.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11428367..11442566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067071.8NP_499472.1  Processed sterol regulatory element binding protein sbp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499472.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XX00
    Conserved Domains (2) summary
    pfam03154
    Location:30272
    Atrophin-1; Atrophin-1 family
    cl00081
    Location:351423
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily