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spe-6 Serine/threonine-protein kinase spe-6 [ Caenorhabditis elegans ]

Gene ID: 176582, updated on 2-Nov-2024

Summary

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Official Symbol
spe-6
Official Full Name
Serine/threonine-protein kinase spe-6
Primary source
WormBase:WBGene00004960
Locus tag
CELE_Y66D12A.20
See related
AllianceGenome:WB:WBGene00004960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in male meiosis chromosome separation; regulation of protein localization; and spermatid differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in sperm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spe-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (11505488..11508930)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Mitochondrial import inner membrane translocase subunit Tim10 Neighboring gene TM2 domain-containing protein Y66D12A.21 Neighboring gene ArgoN domain-containing protein Neighboring gene Suppressor of spindle checkpoint defect 1 Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function. Peterson JJ, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849789, Free PMC Article
  2. The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes. Price KL, et al. Development, 2021 Mar 5. PMID 33558389, Free PMC Article
  3. The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency. Varkey JP, et al. Genetics, 1993 Jan. PMID 8417991, Free PMC Article
  4. A New Player in the Spermiogenesis Pathway of Caenorhabditis elegans. LaMunyon CW, et al. Genetics, 2015 Nov. PMID 26333688, Free PMC Article
  5. Changing synaptic specificities in the nervous system of Caenorhabditis elegans: differentiation of the DD motoneurons. Walthall WW, et al. J Neurobiol, 1993 Dec. PMID 8301267

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.
    Title: Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.
  2. Involved in early and late stages of sperm development in C. elegans. Strong alleles disrupt spermatocyte development. Weaker alleles cause precocious spermatid activation.
    Title: Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase spe-6
NP_499482.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11505488..11508930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067081.4 → NP_499482.1  Serine/threonine-protein kinase spe-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499482.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95PZ9
    Conserved Domains (2) summary
    smart00220
    Location:26 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:25 → 293
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95PZ9.1

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