wah-1 Pyr_redox_2 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wah-1
Official Full Name: Pyr_redox_2 domain-containing protein
Primary source: WormBase:WBGene00006937
Locus tag: CELE_Y56A3A.32
See related: AllianceGenome:WB:WBGene00006937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity. Involved in apoptotic DNA fragmentation and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See wah-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (11990167..11999590)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WAH-1, after its release from mitochondria during apoptosis, promotes plasma membrane phosphatidylserine externalization through its downstream effector, phospholipid scramblase (SCRM-1).
Title: C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C51G7.a (e-PCR)
- UniSTS:324058

Y56A3A.32 (e-PCR)
- UniSTS:321772

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD(P)H oxidase H2O2-forming activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Pyr_redox_2 domain-containing protein

NP_001263729.1

Confirmed by transcript evidence

NP_499564.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11990167..11999590

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067163.6 → NP_499564.2 Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499564.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8HJ11, Q9U229

Conserved Domains (2) summary

pfam07992
Location:242 → 551

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14721
Location:574 → 669

AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
NM_001276800.3 → NP_001263729.1 Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263729.1

Status: REVIEWED

UniProtKB/TrEMBL

K8ESD4

Conserved Domains (3) summary

pfam07992
Location:24 → 333

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14721
Location:356 → 451

AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

cl17037
Location:131 → 201

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily