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nob-1 Homeobox protein nob-1 [ Caenorhabditis elegans ]

Gene ID: 176641, updated on 9-Dec-2024

Summary

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Official Symbol
nob-1
Official Full Name
Homeobox protein nob-1
Primary source
WormBase:WBGene00003779
Locus tag
CELE_Y75B8A.2
See related
AllianceGenome:WB:WBGene00003779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of miRNA transcription; and positive regulation of nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including head muscle; intestine; linker cell; nervous system; and tail. Orthologous to several human genes including HOXA9 (homeobox A9); HOXB9 (homeobox B9); and HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nob-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (12077793..12084316, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase Neighboring gene Homeobox protein php-3 Neighboring gene ncRNA Neighboring gene Carboxylesterase type B domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A negative regulatory loop between microRNA and Hox gene controls posterior identities in Caenorhabditis elegans. Zhao Z, et al. PLoS Genet, 2010 Sep 2. PMID 20824072, Free PMC Article
  2. The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development. Chen Z, et al. Mol Cell Biol, 2004 Sep. PMID 15314147, Free PMC Article
  3. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Van Auken K, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781051, Free PMC Article
  4. Hox Gene Loss during Dynamic Evolution of the Nematode Cluster. Aboobaker AA, et al. Curr Biol, 2003 Jan 8. PMID 12526742
  5. Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans. Zheng C, et al. Neuron, 2015 Nov 4. PMID 26539892, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox protein nob-1
NP_001367008.1
  • Confirmed by transcript evidence
NP_001369824.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12077793..12084316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383007.2 → NP_001369824.1  Homeobox protein nob-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFY5, G5EGL1, Q7K756, Q7KKJ1
    Conserved Domains (1) summary
    pfam00046
    Location:165 → 219
    Homeobox; Homeobox domain

  2. NM_001379944.1 → NP_001367008.1  Homeobox protein nob-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00046
    Location:14 → 68
    Homeobox; Homeobox domain

RNA

  1. NR_147825.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFY5.2

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