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Y75B8A.24 1-phosphatidylinositol 4-kinase [ Caenorhabditis elegans ]

Gene ID: 176653, updated on 9-Dec-2024

Summary

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Official Symbol
Y75B8A.24
Official Full Name
1-phosphatidylinositol 4-kinase
Primary source
WormBase:WBGene00013557
Locus tag
CELE_Y75B8A.24
See related
AllianceGenome:WB:WBGene00013557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Predicted to be active in cytoplasm and plasma membrane. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to several human genes including PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y75B8A.24 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (12251494..12273752, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene RanBD1 domain-containing protein Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4-kinase
NP_499596.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12251494..12273752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067195.6 → NP_499596.2  1-phosphatidylinositol 4-kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499596.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XW63
    Conserved Domains (2) summary
    cd00871
    Location:1544 → 1720
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:1781 → 2105
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
Nucleotide Protein
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