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tat-1 Phospholipid-transporting ATPase tat-1 [ Caenorhabditis elegans ]

Gene ID: 176666, updated on 9-Dec-2024

Summary

Official Symbol
tat-1
Official Full Name
Phospholipid-transporting ATPase tat-1
Primary source
WormBase:WBGene00013034
Locus tag
CELE_Y49E10.11
See related
AllianceGenome:WB:WBGene00013034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including lysosome organization; phospholipid translocation; and regulation of phagocytosis, engulfment. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and endosome. Is expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to several human genes including ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See tat-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
20
Sequence:
Chromosome: III; NC_003281.10 (12398901..12421718, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Proteoglycan 4 Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Pharynx and intestine in excess protein 1 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene putative small nuclear ribonucleoprotein E

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine floppase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Phospholipid-transporting ATPase tat-1
NP_001022894.1
  • Confirmed by transcript evidence
NP_001255165.1
  • Confirmed by transcript evidence
NP_001367088.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12398901..12421718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027723.3NP_001022894.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0P289, Q7JK70, Q9U280
    Conserved Domains (5) summary
    TIGR01652
    Location:281036
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:446545
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:1679
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:7911043
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:745789
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_001268236.3NP_001255165.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U280
    Conserved Domains (6) summary
    TIGR01652
    Location:281036
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:85178
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:446545
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:1679
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:7911043
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:745789
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. NM_001379952.2NP_001367088.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd02073
    Location:30922
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C