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tpst-1 Protein-tyrosine sulfotransferase A [ Caenorhabditis elegans ]

Gene ID: 176684, updated on 4-Jan-2025

Summary

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Official Symbol
tpst-1
Official Full Name
Protein-tyrosine sulfotransferase A
Primary source
WormBase:WBGene00013737
Locus tag
CELE_Y111B2A.15
See related
AllianceGenome:WB:WBGene00013737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein-tyrosine sulfotransferase activity. Involved in several processes, including collagen metabolic process; cuticle development involved in collagen and cuticulin-based cuticle molting cycle; and regulation of nematode larval development. Located in trans-Golgi network. Is expressed in head neurons and hypodermis. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1) and TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tpst-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (12652346..12662286, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor IIA subunit 2 Neighboring gene HUN domain-containing protein;Hpc2-related domain-containing protein Neighboring gene ncRNA Neighboring gene TAFII55 protein conserved region domain-containing protein Neighboring gene Elongator complex protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans. Kim TH, et al. Mol Cells, 2010 Apr. PMID 20229090
  2. Requirement of tyrosylprotein sulfotransferase-A for proper cuticle formation in the nematode C. elegans. Kim TH, et al. FEBS Lett, 2005 Jan 3. PMID 15620690
  3. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Beisswanger R, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736702, Free PMC Article
  4. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang YB, et al. J Biol Chem, 1998 Sep 18. PMID 9733778
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data confirmed that worm TPST-1 is localized to the trans-Golgi network (TGN).
    Title: Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine sulfation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein-tyrosine sulfotransferase A
NP_499646.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12652346..12662286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067245.6 → NP_499646.3  Protein-tyrosine sulfotransferase A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499646.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77081, Q9NEW9
    Conserved Domains (1) summary
    pfam13469
    Location:70 → 257
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77081.1

Gene LinkOut

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