unc-25 Glutamate decarboxylase;Glutamate decarboxylase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-25
Official Full Name: Glutamate decarboxylase;Glutamate decarboxylase 1
Primary source: WormBase:WBGene00006762
Locus tag: CELE_Y37D8A.23
See related: AllianceGenome:WB:WBGene00006762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in several cellular components, including inhibitory synapse; perikaryon; and synaptic vesicle. Is expressed in neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; diabetes mellitus (multiple); and drug psychosis. Orthologous to human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-25 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (12942651..12949883)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37D8A.23 (e-PCR)
- UniSTS:319748

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables glutamate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Glutamate decarboxylase;Glutamate decarboxylase 1

NP_001022831.1

Confirmed by transcript evidence

NP_001022832.1

Confirmed by transcript evidence

NP_499689.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12942651..12949883

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067288.6 → NP_499689.1 Glutamate decarboxylase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499689.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDB7

Conserved Domains (1) summary

cd06450
Location:102 → 503

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_001027660.4 → NP_001022831.1 Glutamate decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022831.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4E0

Conserved Domains (1) summary

cl18945
Location:62 → 424

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001027661.6 → NP_001022832.1 Glutamate decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022832.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4D9

Conserved Domains (1) summary

cd06450
Location:27 → 428

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...