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dhhc-8 Palmitoyltransferase [ Caenorhabditis elegans ]

Gene ID: 176731, updated on 9-Dec-2024

Summary

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Official Symbol
dhhc-8
Official Full Name
Palmitoyltransferase
Primary source
WormBase:WBGene00012718
Locus tag
CELE_Y39E4B.7
See related
AllianceGenome:WB:WBGene00012718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5) and ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhhc-8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (13107692..13118689)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene IK cytokine;Smad nuclear-interacting protein 1 Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Zwei Ig domain protein zig-8 Neighboring gene Beta-1,3-galactosyltransferase bre-2;Hexosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Palmitoyltransferase
NP_001370072.1
  • Confirmed by transcript evidence
NP_001407508.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13107692..13118689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001420559.1 → NP_001407508.1  Palmitoyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBU4

  2. NM_001383019.3 → NP_001370072.1  Palmitoyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2K0
    Conserved Domains (1) summary
    pfam01529
    Location:98 → 228
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein
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