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nud-1 Nuclear migration protein nudC [ Caenorhabditis elegans ]

Gene ID: 176754, updated on 4-Jan-2025

Summary

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Official Symbol
nud-1
Official Full Name
Nuclear migration protein nudC
Primary source
WormBase:WBGene00003829
Locus tag
CELE_F53A2.4
See related
AllianceGenome:WB:WBGene00003829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity and unfolded protein binding activity. Involved in several processes, including GABAergic synaptic transmission; chaperone-mediated protein folding; and pronuclear migration. Predicted to be located in synapse. Predicted to be active in cytoplasm. Is expressed in gonad; hypodermis; intestine; and neurons. Used to study epilepsy and lissencephaly. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nud-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (13341527..13342608)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Phosphoprotein Neighboring gene Protein Dr1 Neighboring gene Eukaryotic translation initiation factor 4E-1;eIF-4F 25 kDa subunit Neighboring gene 3-ketoacyl-CoA thiolase, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Faircloth LM, et al. Cell Stress Chaperones, 2009 Jan. PMID 18626791, Free PMC Article
  2. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Aumais JP, et al. J Cell Sci, 2003 May 15. PMID 12679384
  3. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Campeiro JD, et al. Neurochem Int, 2021 Jul. PMID 33872680
  4. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. Monte GG, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2019 Jun 8. PMID 30578843
  5. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe AL, et al. Dev Genes Evol, 2001 Sep. PMID 11685578

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear migration protein nudC
NP_499749.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13341527..13342608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067348.8 → NP_499749.1  Nuclear migration protein nudC [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE74
    Conserved Domains (3) summary
    cd06492
    Location:161 → 247
    p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
    PTZ00121
    Location:54 → 174
    PTZ00121; MAEBL; Provisional
    pfam14050
    Location:6 → 40
    Nudc_N; N-terminal conserved domain of Nudc
Nucleotide Protein
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