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ant-1.1 ADP/ATP translocase [ Caenorhabditis elegans ]

Gene ID: 176773, updated on 9-Dec-2024

Summary

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Official Symbol
ant-1.1
Official Full Name
ADP/ATP translocase
Primary source
WormBase:WBGene00006439
Locus tag
CELE_T27E9.1
See related
AllianceGenome:WB:WBGene00006439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP:ADP antiporter activity. Involved in determination of adult lifespan; mitochondrion organization; and positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and vulva. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ant-1.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (13463163..13464652)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene Major sperm protein Neighboring gene Cytochrome b-c1 complex subunit 6 Neighboring gene Cyclin-dependent-like kinase 5 Neighboring gene BTB domain-containing protein Neighboring gene Phosphatidylserine synthase Neighboring gene SET domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic characterization of Tv-ant-1, a Caenorhabditis elegans tag-61 homologue from the parasitic nematode Trichostrongylus vitrinus. Hu M, et al. Gene, 2007 Aug 1. PMID 17512141
  2. Elucidating ANTs in worms using genomic and bioinformatic tools--biotechnological prospects? Hu M, et al. Biotechnol Adv, 2010 Jan-Feb. PMID 19770033
  3. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. Farina F, et al. Dev Dyn, 2008 Jun. PMID 18498090
  4. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Shen Q, et al. Mol Cell Biol, 2009 Jul. PMID 19414600, Free PMC Article
  5. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Zhou B, et al. Cell, 2019 Apr 4. PMID 30929899, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP/ATP translocase
NP_001022799.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13463163..13464652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027628.8 → NP_001022799.1  ADP/ATP translocase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45865, Q17407
    Conserved Domains (2) summary
    PTZ00169
    Location:10 → 300
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:8 → 107
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
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