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rml-1 UTP--glucose-1-phosphate uridylyltransferase [ Caenorhabditis elegans ]

Gene ID: 176814, updated on 14-Nov-2024

Summary

Official Symbol
rml-1
Official Full Name
UTP--glucose-1-phosphate uridylyltransferase
Primary source
WormBase:WBGene00010665
Locus tag
CELE_K08E3.5
See related
AllianceGenome:WB:WBGene00010665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See rml-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (13764030..13768092, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene Transducer of Cdc42-dependent actin assembly protein 2 homolog Neighboring gene DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase parkin;RBR-type E3 ubiquitin transferase;Ubiquitin-like domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

General protein information

Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
NP_001022671.1
  • Confirmed by transcript evidence
NP_001379213.1
  • Confirmed by transcript evidence
NP_001379395.1
  • Confirmed by transcript evidence
NP_499841.1
  • Confirmed by transcript evidence
NP_499842.1
  • Confirmed by transcript evidence
NP_499843.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13764030..13768092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067441.4NP_499842.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS5
    Conserved Domains (1) summary
    pfam01704
    Location:73487
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  2. NM_001027500.7NP_001022671.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q69Z13
    Conserved Domains (1) summary
    pfam01704
    Location:44458
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  3. NM_001392235.1NP_001379213.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS6
    Conserved Domains (1) summary
    pfam01704
    Location:58474
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  4. NM_001392234.1NP_001379395.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86D12
    Conserved Domains (1) summary
    pfam01704
    Location:45461
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  5. NM_067440.8NP_499841.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS4
    Conserved Domains (1) summary
    pfam01704
    Location:62476
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  6. NM_067442.6NP_499843.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499843.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQE5
    Conserved Domains (1) summary
    pfam01704
    Location:73462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase