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tpa-1 Protein kinase C-like 1 [ Caenorhabditis elegans ]

Gene ID: 176825, updated on 2-Nov-2024

Summary

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Official Symbol
tpa-1
Official Full Name
Protein kinase C-like 1
Primary source
WormBase:WBGene00006599
Locus tag
CELE_B0545.1
See related
AllianceGenome:WB:WBGene00006599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; peptidyl-serine phosphorylation; and positive regulation of antimicrobial peptide production. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Used to study Down syndrome. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tpa-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (91980..110819)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SCP domain-containing protein Neighboring gene HAT C-terminal dimerization domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans. Tabuse Y, et al. Science, 1989 Mar 31. PMID 2538925
  2. The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca(2+)-independent protein kinase Cs: evidence by complete genomic and complementary DNA sequences of the tpa-1 gene. Sano T, et al. J Mol Biol, 1995 Aug 25. PMID 7658466
  3. Origin, properties, and regulated expression of multiple mRNAs encoded by the protein kinase C1 gene of Caenorhabditis elegans. Land M, et al. J Biol Chem, 1994 May 20. PMID 8182089
  4. A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans. Tabuse Y, et al. Carcinogenesis, 1983. PMID 6861282
  5. Molecular evidence for the direct involvement of a protein kinase C in developmental and behavioural susceptibility to tumour-promoting phorbol esters in Caenorhabditis elegans. Tabuse Y, et al. Biochem J, 1995 Nov 15. PMID 7492337, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
    Title: A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
  2. In a screen for mutants that fail to express nlp-29 following fungal infection, alleles of tpa-1 were isolated, homologous to the mammalian protein kinase C (PKC) delta.
    Title: Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Protein kinase C-like 1
NP_001359809.1
  • Confirmed by transcript evidence
NP_001379590.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    91980..110819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392238.1 → NP_001379590.1  Protein kinase C-like 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34722
    Conserved Domains (3) summary
    cd05592
    Location:379 → 700
    STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
    cd20834
    Location:159 → 219
    C1_nPKC_theta-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins
    cd20837
    Location:238 → 287
    C1_nPKC_theta-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins

  2. NM_001372684.2 → NP_001359809.1  Protein kinase C-like 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd05592
    Location:242 → 563
    STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
    pfam00130
    Location:101 → 151
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34722.2

Gene LinkOut

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