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grld-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176827, updated on 4-Jan-2025

Summary

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Official Symbol
grld-1
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00017929
Locus tag
CELE_F29C4.7
See related
AllianceGenome:WB:WBGene00017929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Located in nucleus. Is expressed in epithelial cell; lateral ganglion; muscle cell; and neurons. Orthologous to human RBM15 (RNA binding motif protein 15) and RBM15B (RNA binding motif protein 15B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See grld-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (121797..125931, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Cytoplasmic tRNA 2-thiolation protein 1 Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation. Wang GJ, et al. Nat Neurosci, 2010 Dec. PMID 21037582, Free PMC Article
  2. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Samuelson AV, et al. Cold Spring Harb Symp Quant Biol, 2007. PMID 18419309
  3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RRM domain-containing protein
NP_741283.1
  • Confirmed by transcript evidence
NP_741284.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    121797..125931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171237.8 → NP_741283.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYB8
    Conserved Domains (3) summary
    cd12310
    Location:253 → 324
    RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
    pfam07744
    Location:376 → 482
    SPOC; SPOC domain
    cl17169
    Location:167 → 246
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_171238.5 → NP_741284.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXG5
    Conserved Domains (2) summary
    cd12310
    Location:253 → 324
    RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
    cl17169
    Location:167 → 246
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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