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pnp-1 Purine nucleoside phosphorylase [ Caenorhabditis elegans ]

Gene ID: 176851, updated on 4-Jan-2025

Summary

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Official Symbol
pnp-1
Official Full Name
Purine nucleoside phosphorylase
Primary source
WormBase:WBGene00019298
Locus tag
CELE_K02D7.1
See related
AllianceGenome:WB:WBGene00019298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable purine-nucleoside phosphorylase activity. Involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in epithelial cell; head neurons; and intestine. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pnp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (292433..298280, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Sugar transporter SWEET1 Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. Martell J, et al. Cell Chem Biol, 2016 Aug 18. PMID 27499530, Free PMC Article
  2. Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes. Venzon M, et al. Cell Host Microbe, 2022 Jun 8. PMID 35413267, Free PMC Article
  3. Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection. Olaitan AO, et al. PLoS Genet, 2018 Sep. PMID 30265660, Free PMC Article
  4. The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. Tecle E, et al. PLoS Pathog, 2021 Apr. PMID 33878133, Free PMC Article
  5. The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans. Lažetić V, et al. Nat Commun, 2022 Jan 10. PMID 35013162, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables purine-nucleoside phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Purine nucleoside phosphorylase
NP_001368342.1
  • Confirmed by transcript evidence
NP_001379888.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    292433..298280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392243.1 → NP_001379888.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61217
    Conserved Domains (1) summary
    TIGR01700
    Location:44 → 297
    PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

  2. NM_001380002.1 → NP_001368342.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PSA1
    Conserved Domains (1) summary
    TIGR01700
    Location:61 → 314
    PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific
Nucleotide Protein
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