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ddx-46 ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase [ Caenorhabditis elegans ]

Gene ID: 176943, updated on 2-Nov-2024

Summary

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Official Symbol
ddx-46
Official Full Name
ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase
Primary source
WormBase:WBGene00018776
Locus tag
CELE_F53H1.1
See related
AllianceGenome:WB:WBGene00018776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in P granule. Predicted to be active in nucleus. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ddx-46 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (1297222..1309650, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S15;DNA_pol_B_exo1 domain-containing protein;Transposase;Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene PHD-type domain-containing protein Neighboring gene UDENN domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article
  2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  3. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
  4. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase
NP_001033411.1
  • Confirmed by transcript evidence
NP_001294485.1
  • Confirmed by transcript evidence
NP_001294486.1
  • Confirmed by transcript evidence
NP_001294487.1
  • Confirmed by transcript evidence
NP_001368269.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1297222..1309650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038322.5 → NP_001033411.1  ATP-dependent RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965K2
    Conserved Domains (3) summary
    COG0513
    Location:276 → 793
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:534 → 655
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:316 → 514
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

  2. NM_001307556.3 → NP_001294485.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294485.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRR4
    Conserved Domains (3) summary
    COG0513
    Location:276 → 744
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:534 → 655
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:316 → 514
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

  3. NM_001307558.3 → NP_001294487.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBN2
    Conserved Domains (3) summary
    COG0513
    Location:261 → 607
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:397 → 518
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:260 → 377
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001307557.3 → NP_001294486.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEV8
    Conserved Domains (3) summary
    COG0513
    Location:261 → 656
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:397 → 518
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:260 → 377
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001380041.1 → NP_001368269.1  RNA helicase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBH1
    Conserved Domains (1) summary
    cl00098
    Location:140 → 235
    KH-I; K homology (KH) RNA-binding domain, type I
Nucleotide Protein
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