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nadk-1 NAD(+) kinase [ Caenorhabditis elegans ]

Gene ID: 176954, updated on 4-Jan-2025

Summary

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Official Symbol
nadk-1
Official Full Name
NAD(+) kinase
Primary source
WormBase:WBGene00022307
Locus tag
CELE_Y77E11A.2
See related
AllianceGenome:WB:WBGene00022307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable NAD+ kinase activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nadk-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (1457075..1459521)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Calpain catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene GRAM domain-containing protein Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
  2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  4. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAD(+) kinase
NP_500084.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1457075..1459521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067683.4 → NP_500084.2  NAD(+) kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500084.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4A9
    Conserved Domains (1) summary
    cl01255
    Location:69 → 248
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
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