ngn-1 Helix-loop-helix protein ngn-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ngn-1
Official Full Name: Helix-loop-helix protein ngn-1
Primary source: WormBase:WBGene00003595
Locus tag: CELE_Y69A2AR.29
See related: AllianceGenome:WB:WBGene00003595
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in several processes, including axon development; negative regulation of gliogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ABara; ABaraappaa; ABarp; ABplpapaaa; and ventral ganglion. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to several human genes including NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ngn-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (2626062..2628271, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System.
Title: ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y69A2A_7278.i (e-PCR)
- UniSTS:324201

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Helix-loop-helix protein ngn-1

NP_500236.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2626062..2628271 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067835.5 → NP_500236.1 Helix-loop-helix protein ngn-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95XG7

Conserved Domains (1) summary

cl00081
Location:63 → 119

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily