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lin-22 Helix-loop-helix protein lin-22 [ Caenorhabditis elegans ]

Gene ID: 177082, updated on 9-Dec-2024

Summary

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Official Symbol
lin-22
Official Full Name
Helix-loop-helix protein lin-22
Primary source
WormBase:WBGene00003008
Locus tag
CELE_Y54G2A.1
See related
AllianceGenome:WB:WBGene00003008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and uterus. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lin-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (3019738..3023304)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Vitellogenin Regulating Protein Neighboring gene ncRNA Neighboring gene Protein NDNF C-terminal domain-containing protein Neighboring gene HECT-type E3 ubiquitin transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number. Katsanos D, et al. PLoS Biol, 2017 Nov. PMID 29108019, Free PMC Article
  2. The synaptonemal complexes of Caenorhabditis elegans: pachytene karyotype analysis of hermaphrodites from the recessive him-5 and him-7 mutants. Goldstein P. J Cell Sci, 1986 Jun. PMID 3793776
  3. Targeted DamID in C. elegans reveals a direct role for LIN-22 and NHR-25 in antagonizing the epidermal stem cell fate. Katsanos D, et al. Sci Adv, 2022 Feb 4. PMID 35119932, Free PMC Article
  4. Age-related changes in the meiotic chromosomes of the nematode Caenorhabditis elegans. Goldstein P, et al. Mech Ageing Dev, 1987 Sep 30. PMID 3431155
  5. A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit. Weston K, et al. Nucleic Acids Res, 1989 Mar 11. PMID 2928124, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epidermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Helix-loop-helix protein lin-22
NP_500281.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3019738..3023304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067880.6 → NP_500281.1  Helix-loop-helix protein lin-22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500281.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF76
    Conserved Domains (1) summary
    cd11410
    Location:29 → 82
    bHLH_O_HES; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EF76.1

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