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ltah-1.2 Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177123, updated on 4-Jan-2025

Summary

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Official Symbol
ltah-1.2
Official Full Name
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein
Primary source
WormBase:WBGene00022610
Locus tag
CELE_ZC416.6
See related
AllianceGenome:WB:WBGene00022610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Involved in negative regulation of fatty acid transport; regulation of lipid storage; and regulation of peptide transport. Predicted to be active in cytosol. Is expressed in intestine. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ltah-1.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (3609218..3613072, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BRCT domain-containing protein Neighboring gene Stress-activated protein kinase JNK Neighboring gene Choline O-acetyltransferase Neighboring gene Vesicular acetylcholine transporter unc-17 Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
  2. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article
  3. A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans. Benner J, et al. PLoS One, 2011. PMID 21980510, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of fatty acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein
NP_001368204.1
  • Confirmed by transcript evidence
NP_500385.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3609218..3613072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067984.7 → NP_500385.1  Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44183
    Conserved Domains (2) summary
    cd09599
    Location:12 → 455
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:500 → 614
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  2. NM_001380155.1 → NP_001368204.1  Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PAP4
    Conserved Domains (2) summary
    cd09599
    Location:1 → 364
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:409 → 523
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
Nucleotide Protein
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