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map-1 C6H2-type domain-containing protein;Methionine aminopeptidase [ Caenorhabditis elegans ]

Gene ID: 177128, updated on 4-Jan-2025

Summary

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Official Symbol
map-1
Official Full Name
C6H2-type domain-containing protein;Methionine aminopeptidase
Primary source
WormBase:WBGene00003129
Locus tag
CELE_Y37E11AL.7
See related
AllianceGenome:WB:WBGene00003129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosolic ribosome. Predicted to be active in cytosol. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See map-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (3683537..3686865, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene TAF6 C-terminal HEAT repeat domain-containing protein Neighboring gene Retrotransposon gag protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation. Boxem M, et al. FEBS Lett, 2004 Oct 8. PMID 15474045
  2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C6H2-type domain-containing protein;Methionine aminopeptidase
NP_001368273.1
  • Confirmed by transcript evidence
NP_001417869.1
  • Confirmed by transcript evidence
NP_500396.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3683537..3686865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067995.4 → NP_500396.2  Methionine aminopeptidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500396.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965Y1
    Conserved Domains (3) summary
    PLN03158
    Location:9 → 356
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:118 → 355
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:11 → 50
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

  2. NM_001380156.1 → NP_001368273.1  Methionine aminopeptidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBI7
    Conserved Domains (1) summary
    PLN03158
    Location:1 → 57
    PLN03158; methionine aminopeptidase; Provisional

  3. NM_001430921.1 → NP_001417869.1  C6H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PER3
Nucleotide Protein
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