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smgl-2 ATP-dependent RNA helicase DHX34 [ Caenorhabditis elegans ]

Gene ID: 177135, updated on 2-Nov-2024

Summary

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Official Symbol
smgl-2
Official Full Name
ATP-dependent RNA helicase DHX34
Primary source
WormBase:WBGene00021365
Locus tag
CELE_Y37E11AM.1
See related
AllianceGenome:WB:WBGene00021365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and helicase activity. Involved in nuclear-transcribed mRNA catabolic process. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smgl-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (3726164..3735496)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 3-dehydrosphinganine reductase;3-ketodihydrosphingosine reductase Neighboring gene Ribonuclease P Neighboring gene Anoct_dimer domain-containing protein;Protein XAP5 CIRCADIAN TIMEKEEPER Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
  2. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX34
NP_001294374.1
  • Confirmed by transcript evidence
NP_001368241.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3726164..3735496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307445.3 → NP_001294374.1  ATP-dependent RNA helicase DHX34 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRA5
    Conserved Domains (5) summary
    smart00487
    Location:130 → 330
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:561 → 635
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:161 → 296
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:350 → 480
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:775 → 888
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_001380158.1 → NP_001368241.1  ATP-dependent RNA helicase DHX34 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEF8
    Conserved Domains (2) summary
    COG1643
    Location:1 → 460
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:543 → 643
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
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