nape-2 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nape-2
Official Full Name: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2
Primary source: WormBase:WBGene00021370
Locus tag: CELE_Y37E11AR.3
See related: AllianceGenome:WB:WBGene00021370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in N-acylethanolamine metabolic process. Located in neuron projection. Is expressed in pharynx; somatic nervous system; spermatheca; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nape-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (3735845..3738925, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37E11A_93.d (e-PCR)
- UniSTS:323627

Y37E11A_93.c (e-PCR)
- UniSTS:322741

STS4-123 (e-PCR)
- UniSTS:242112

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2

NP_001368057.1

Confirmed by transcript evidence

NP_001380074.1

Confirmed by transcript evidence

NP_741361.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3735845..3738925 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392287.1 → NP_001380074.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MXT4, Q965X8, Q965X9

Conserved Domains (1) summary

cl23716
Location:86 → 280

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
NM_001380159.1 → NP_001368057.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl23716
Location:107 → 301

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
NM_171307.5 → NP_741361.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741361.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MXT4

Conserved Domains (1) summary

cl23716
Location:107 → 301

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain