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mt-Nd4l NADH dehydrogenase 4L, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17720, updated on 9-Dec-2024

Summary

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Official Symbol
mt-Nd4lprovided by MGI
Official Full Name
NADH dehydrogenase 4L, mitochondrialprovided by MGI
Primary source
MGI:MGI:102497
See related
AllianceGenome:MGI:102497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND4L
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in ATP synthesis coupled electron transport and proton transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy and diabetes mellitus. Orthologous to human MT-ND4L (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mt-Nd4l in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (9877..10173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (9877..10173)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 3 Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4 Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Revisiting the mouse mitochondrial DNA sequence. Bayona-Bafaluy MP, et al. Nucleic Acids Res, 2003 Sep 15. PMID 12954771, Free PMC Article
  2. Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains. Yu X, et al. Genome Res, 2009 Jan. PMID 19037013, Free PMC Article
  3. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
  4. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • URF4L

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Names
NADH dehydrogenase subunit 4L
NP_904336.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    9877..10173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904336.1 NADH dehydrogenase subunit 4L (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03903
    UniProtKB/TrEMBL
    A0A0C4G448, Q7JD00, Q7YBV2, Q9MD77
    Related
    ENSMUSP00000081021.1
    Conserved Domains (1) summary
    MTH00107
    Location:1 → 98
    ND4L; NADH dehydrogenase subunit 4L; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03903.2

Gene LinkOut

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