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best-6 Bestrophin-6 [ Caenorhabditis elegans ]

Gene ID: 177270, updated on 4-Jan-2025

Summary

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Official Symbol
best-6
Official Full Name
Bestrophin-6
Primary source
WormBase:WBGene00015628
Locus tag
CELE_C09B9.3
See related
AllianceGenome:WB:WBGene00015628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See best-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (5026513..5029078, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bestrophin-6
NP_001255268.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5026513..5029078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268339.2 → NP_001255268.1  Bestrophin-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D0VWM1, Q17851
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 312
    Bestrophin; Bestrophin, RFP-TM, chloride channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17851.3

Gene LinkOut

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Molecular Biology Databases
Research Materials