ivd-1 Isovaleryl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ivd-1
Official Full Name: Isovaleryl-CoA dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00015326
Locus tag: CELE_C02B10.1
See related: AllianceGenome:WB:WBGene00015326
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-methylbutanoyl-CoA dehydrogenase activity. Involved in regulation of response to oxidative stress. Predicted to be active in mitochondrion. Is expressed in head; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-methylbutanoyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-methylbutanoyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_500720.1

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