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soc-2 Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2 [ Caenorhabditis elegans ]

Gene ID: 177286, updated on 2-Nov-2024

Summary

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Official Symbol
soc-2
Official Full Name
Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2
Primary source
WormBase:WBGene00004929
Locus tag
CELE_AC7.2
See related
AllianceGenome:WB:WBGene00004929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables small GTPase binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of Ras protein signal transduction; and vulval development. Is expressed in several structures, including hypodermis; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See soc-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (5127041..5152491, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane 9 superfamily member Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo. Polanska UM, et al. J Biol Chem, 2009 Nov 27. PMID 19801543, Free PMC Article
  2. LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans. Legouis R, et al. Nat Cell Biol, 2000 Jul. PMID 10878806
  3. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Cordeddu V, et al. Nat Genet, 2009 Sep. PMID 19684605, Free PMC Article
  4. An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. DeVore DL, et al. Cell, 1995 Nov 17. PMID 7585964
  5. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Selfors LM, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618511, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables volume-sensitive anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2
NP_001021259.1
  • Confirmed by transcript evidence
NP_001293758.1
  • Confirmed by transcript evidence
NP_001293759.1
  • Partially confirmed by transcript evidence
NP_741391.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5127041..5152491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306829.3 → NP_001293758.1  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJ50
    Conserved Domains (2) summary
    PLN00113
    Location:150 → 605
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:148 → 169
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_171332.5 → NP_741391.2  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741391.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22875
    Conserved Domains (3) summary
    cd00116
    Location:119 → 201
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:75 → 96
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:119 → 176
    LRR_8; Leucine rich repeat

  3. NM_001026088.5 → NP_001021259.1  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021259.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77472, Q22875, Q8MPP6
    Conserved Domains (3) summary
    cd00116
    Location:120 → 202
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:76 → 97
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:120 → 177
    LRR_8; Leucine rich repeat

  4. NM_001306830.4 → NP_001293759.1  Leucine-rich repeat protein SHOC-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK98
    Conserved Domains (2) summary
    PLN00113
    Location:68 → 523
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:66 → 87
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22875.3

Gene LinkOut

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