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swsn-6 Actin-related protein 4 [ Caenorhabditis elegans ]

Gene ID: 177325, updated on 2-Nov-2024

Summary

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Official Symbol
swsn-6
Official Full Name
Actin-related protein 4
Primary source
WormBase:WBGene00022774
Locus tag
CELE_ZK616.4
See related
AllianceGenome:WB:WBGene00022774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in chromatin remodeling; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex and SWI/SNF complex. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to several human genes including ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See swsn-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (5395033..5396969)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ER membrane protein complex subunit 4 Neighboring gene ncRNA Neighboring gene CHCH domain-containing protein Neighboring gene CHCH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Mathies LD, et al. Proc Natl Acad Sci U S A, 2015 Mar 10. PMID 25713357, Free PMC Article
  2. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
  3. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Actin-related protein 4
NP_500801.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5395033..5396969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068400.7 → NP_500801.2  Actin-related protein 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500801.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4N4
    Conserved Domains (2) summary
    pfam00022
    Location:11 → 436
    Actin; Actin
    cl17037
    Location:10 → 435
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
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