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pck-3 phosphoenolpyruvate carboxykinase (GTP) [ Caenorhabditis elegans ]

Gene ID: 177360, updated on 14-Nov-2024

Summary

Official Symbol
pck-3
Official Full Name
phosphoenolpyruvate carboxykinase (GTP)
Primary source
WormBase:WBGene00019151
Locus tag
CELE_H04M03.1
See related
AllianceGenome:WB:WBGene00019151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to dexamethasone stimulus; and gluconeogenesis. Predicted to be active in cytosol. Is expressed in excretory cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See pck-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (5896641..5899112)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group B Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ras-associating domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoenolpyruvate carboxykinase activity IEA
Inferred from Electronic Annotation
more info
 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerol biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in propionate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
phosphoenolpyruvate carboxykinase (GTP)
NP_500887.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5896641..5899112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068486.5NP_500887.1  phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYQ8
    Conserved Domains (1) summary
    cl22860
    Location:60624
    PEPCK_HprK; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...