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acox-3 Acyl-coenzyme A oxidase acox-3 [ Caenorhabditis elegans ]

Gene ID: 177386, updated on 9-Dec-2024

Summary

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Official Symbol
acox-3
Official Full Name
Acyl-coenzyme A oxidase acox-3
Primary source
WormBase:WBGene00019060
Locus tag
CELE_F58F9.7
See related
AllianceGenome:WB:WBGene00019060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Is expressed in intestinal cell. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acox-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (6245358..6248492, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27551084, Free PMC Article
  2. Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths. Zhang X, et al. ACS Chem Biol, 2018 Apr 20. PMID 29537254
  3. Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans. Wang Y, et al. J Biol Chem, 2022 Aug. PMID 35752365, Free PMC Article
  4. Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors. Gao C, et al. Sci China Life Sci, 2021 Dec. PMID 34755252
  5. Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans. Zhou Y, et al. Elife, 2018 Jun 4. PMID 29863473, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
NOT enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables pristanoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ascaroside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Acyl-coenzyme A oxidase acox-3
NP_500943.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6245358..6248492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068542.8 → NP_500943.1  Acyl-coenzyme A oxidase acox-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500943.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20992
    Conserved Domains (1) summary
    cd01150
    Location:4 → 642
    AXO; Peroxisomal acyl-CoA oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20992.1

Gene LinkOut

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